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Figure 1


FIGURE 1.. Geometric mean red blood cell folate concentrations over time after 24 wk of supplementation with 400 µg folic acid/d ({blacktriangleup}, n = 34), 416 µg [6S]-5-methyltetrahydrofolate ([6S]-5-MTHF)/d ({blacksquare}, n = 35), 208 µg [6S]-5-MTHF/d ({diamondsuit}, n = 33), or placebo (•, n = 34). Bars represent 95% CIs. A significant interaction was observed between time and intervention (P < 0.001, repeated-measures ANOVA). The dimension of increase over time (ie, slope) was significantly greater in the group receiving 416 µg [6S]-5-MTHF/d than in the groups receiving 400 µg folic acid/d or 208 µg [6S]-5-MTHF/d (P < 0.001 for both, Tukey's honestly significant difference test) and in the group receiving 400 µg folic acid/d than in the group receiving 208 µg [6S]-5-MTHF/d (P < 0.05, Tukey's honestly significant difference test). *Significantly different from the previous time point within groups, P < 0.05/6 (Bonferroni post hoc test adjusted for multiple comparisons).