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American Journal of Clinical Nutrition, Vol 1, 37-43, Copyright © 1952 by The American Society for Clinical Nutrition, Inc.

HYPOVITAMINEMIA A

Effect of Vitamin A Administration on Plasma Vitamin A Concentration, Conjunctival Changes, Dark Adaptation and Toad Skin

JOHN ESBEN KIRK M.D.1 and MARGARET CHIEFFI M.D.1

1 From the Division of Gerontology, Washington University School of Medicine, and the St. Louis City Infirmary Hospital. St. Louis. Missouri

The effect of vitamin A therapy on the plasma vitamin A concentration, conjunctival lesions, dark adaptation time and toad skin was studied in 23 elderly individuals with hypovitaminemia A. A dose of 30,000 units of natural vitamin A acetate was given daily by mouth for a period of one year.

The treatment resulted in a rise of the mean plasma vitamin A concentration from 5.1 to 44.5 micrograms per 100 cc., at which latter level the plasma vitamin A content was maintained. Following discontinuation of therapy the plasma vitamin A concentration decreased to about 16 micrograms per 100 cc.

A definite beneficial effect on existing localized conjunctival thickening, blepharoconjunctivitis and toad skin was observed, but the response was generally slow.

The adaptation time in 4 out of 17 patients decreased markedly following vitamin A therapy, but in the remaining patients was not influenced significantly.






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Copyright © 1952 by The American Society for Nutrition