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American Journal of Clinical Nutrition, Vol 1, 200-207, Copyright © 1953 by The American Society for Clinical Nutrition, Inc.

PYRIDOXINE DEFICIENCY in the HUMAN INFANT

SELMA E. SNYDERMAN M.D.1, L. EMMETT HOLT JR. M.D.1, ROSARIO CARRETERO M.D.1, and KATHRYN JACOBS M.D.1

1 From the Department of Pediatrics, New York University College of Medicine

Pyridoxine deprivation in two human infants resulted in an arrest of weight gain and failure of the ability to convert tryptophan to N1-methylnicotinamide in both. In one subject, it resulted in convulsive seizures; in the other it provoked a severe microcytic hypochromic anemia. All of these symptoms and signs were corrected by the introduction of pyridoxine into the diet.

The ability to convert tryptophan to N1-methylnicotinamide is suggested as a biochemical test for pyridoxine deficiency in the human.




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