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American Journal of Clinical Nutrition, Vol 10, 107-110, Copyright © 1962 by The American Society for Clinical Nutrition, Inc.

The Effects of Sitosterol, Nicotinic Acid and Triparanol on Fat Tolerance

DONALD BERKOWITZ M.D.1, MILLARD W. CROLL M.D.1, and WILLIAM LIKOFF M.D.1

1 From the Departments of Medicine and Radiology, the Hahnemann Medical College, and the Albert Einstein Medical Center, Philadelphia, Pennsylvania

The effects of sitosterol, nicotinic acid and triparanol have been studied in a group of thirty patients with hypercholesterolemia and abnormal radioactive fat tolerance. In a certain number of cases, a decrease in the cholesterol level occurred with each drug. However, in only one instance was there any significant improvement in the fat tolerance. It is suggested that the restricted hypocholesterol activity of these agents limits their effectiveness as atherosclerotic agents






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Copyright © 1962 by The American Society for Nutrition