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American Journal of Clinical Nutrition, Vol 10, 500-505, Copyright © 1962 by The American Society for Clinical Nutrition, Inc.

Factors Affecting Human Antibody Response

I. Effects of Variations in Dietary Protein Upon the Antigenic Response of Men

ROBERT E. HODGES M.D.1, WILLIAM B. BEAN M.D.1, MARGARET A. OHLSON PH.D.1, and ROBERTA E. BLEILER PH.D.1

1 From the Department of Medicine, University Hospitals, Iowa City, Iowa

Six healthy men were fed diets with low, normal or high contents of protein. One man from each pair received egg yolk or egg yolk and skim milk solids as the sources of protein, the other man received skim milk solids only. The two men receiving the lowest quantity of protein were in negative nitrogen balance. Antibody responses to tetanus and typhoid antigens were poor in the man who ate a low protein diet composed of skim milk solids, but not in his colleague who ate egg yolk protein. As the quantity of egg yolk protein was increased in the diet, the magnitude of antibody response decreased.






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Copyright © 1962 by The American Society for Nutrition