AJCN Tufts Nutrition Symposium, Boston Sept 24-26
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American Journal of Clinical Nutrition, Vol 10, 506-511, Copyright © 1962 by The American Society for Clinical Nutrition, Inc.

Factors Affecting Human Antibody Response

II. Effects of Large Doses of Homologous Gamma Globulin

ROBERT E. HODGES M.D.1, WILLIAM B. BEAN M.D.1, MARGARET A. OHLSON PH.D.1, and ROBERTA E. BLEILER PH.D.1

1 From the Department of Medicine, University Hospitals, Iowa City, Iowa

The effect of administering large doses of human gamma globulin to three healthy men was studied. Three other men served as controls. Intravenous administration of gamma globulin was accompanied by unpleasant but harmless symptoms. Measurements of the concentration of gamma globulin in the serum showed that the amount was approximately doubled. The increase was accompan ed by an accelerated erythrocyte sedimentation rate. No toxic effects of this procedure could be detected in the renal, hepatic or hematopoietic systems. Plasma cells did not disappear from the bone marrow. The response of experimental subjects to tetanus antigens was normal; responses to typhoid H and O antigens and to Asian influenza antigens were less than those of control subjects.






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Copyright © 1962 by The American Society for Nutrition