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American Journal of Clinical Nutrition, Vol 12, 54-65, Copyright © 1963 by The American Society for Clinical Nutrition, Inc.

Cali-Harvard Nutrition Project

I. Megaloblastic Anemia in Kwashiorkor

H. VELEZ M.D.1, J. GHITIS M.D.1, A. PRADILLA M.D.1, and J. J. VITALE SC.D.1

1 From the Departments of Nutrition, Medicine and Pediatrics, Universidad del Valle, Cali, Colombia, S. A., and the Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

Studies on the daily requirements of folic acid for the remission of megaloblastic dysplasia seen in malnourished children (kwashiorkor and marasmus) were carried out. Folic acid, 20 µg. per day given orally (in some cases less), caused a remission in the megaloblastic bone marrow. The value of sideroblast counts in diagnosing bone marrow changes associated with the oral administration of folic acid is discussed.

The changes in serum electrolytes, protein, protein fractions and cholesterol with protein feeding is presented.




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F. A. KLIPSTEIN
Antibiotic Therapy in Tropical Sprue: The Role of Dietary Folic Acid in the Hematologic Remission Associated with Oral Antibiotic Therapy
Ann Intern Med, October 1, 1964; 61(4): 721 - 728.
[Abstract] [PDF]


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Copyright © 1963 by The American Society for Nutrition