AJCN Tufts Nutrition Symposium, Boston Sept 24-26
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American Journal of Clinical Nutrition, Vol 12, 145-149, Copyright © 1963 by The American Society for Clinical Nutrition, Inc.

Retention of Injected Hydroxocobalamin Versus Cyanocobalamin Versus Liver Extract-Bound Cobalamin

VICTOR HERBERT M.D.1, RALPH ZALUSKY M.D.1, and HELEN R. SKEGGS B.S.1

1 From the Thorndike Memorial Laboratory and Second and Fourth (Harvard) Medical Services, Boston City Hospital, the Department of Medicine, Harvard Medical School, Boston, Massachusetts; and the Merck Institute for Therapeutic Research, West Point, Pennsylvania

It is demonstrated in normal subjects and in subjects with vitamin B12 deficiency maintained in remission by monthly injections of cyanocobalamin that the rise in serum cobalamin levels is more sustained after the intramuscular injection of 100 µg of hydroxocobalamin, than after the injection of 100 µg of cyanocobalamin or liver extract cobalamin of equal microbiologic value. Urinary excretion of cobalamin is considerably greater for several days following injection of cyanocobalamin than following injection of hydroxocobalamin or liver extract cobalamin. However, because the serum levels at convenient intervals for therapeutic injections, such as two or four weeks, are not significantly greater after the injection of hydroxocobalamin, any therapeutic advantage of this agent remains to be shown.






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Copyright © 1963 by The American Society for Nutrition