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American Journal of Clinical Nutrition, Vol 12, 445-451, Copyright © 1963 by The American Society for Clinical Nutrition, Inc.

Cali-Harvard Nutrition Project

II. The Erythroid Atrophy of Kwashiorkor and Marasmus

JACOBO GHITIS M.D1, HERNAN VELEZ M.D.1, FRANCISCO LINARES M.D.1, LEONARDO SINISTERRA M.D.1, and JOSEPH J. VITALE SC.D.1

1 From the Departments of Nutrition, Medicine and Pediatrics, Universidad del Valle, Cali, Colombia, South America, and the Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

Erythroid hypoplasia was a consistent finding in children with malnutrition (kwashiorkor and marasmus). With subsequent protein feeding, there was an increased production of normoblasts, and in most cases, erythroid hyperplasia occurred. With increased erythropoiesis, the associated deficiencies became apparent or more marked. It is postulated that the anemia of kwashiorkor is primarily due to the protein deficiency which results in a decreased production of red cell precursors.






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