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American Journal of Clinical Nutrition, Vol 12, 452-454, Copyright © 1963 by The American Society for Clinical Nutrition, Inc.

Cali-Harvard Nutrition Project

III. The Erythroid Atrophy of Severe Protein Deficiency in Monkeys

JACOBO GHITIS M.D.1, ELENA PIAZUELO SC.D.1, and JOSEPH J. VITALE SC.D.1

1 From the Departments of Medicine and Nutrition, Universidad del Valle, Cali, Colombia, South America, and the Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

Erythroid atrophy developed rapidly in Cebus monkeys when they were fed a protein-free diet. When refed, there was an initial erythroid hyperplasia followed by a return to control normoblast counts. The findings confirm the observations previously made in patients with kwashiorkor and marasmus and support the postulate that the basic mechanism producing the anemia of protein deficiency is an atrophy of the erythropoietic tissue.







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