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American Journal of Clinical Nutrition, Vol 13, 277-284, Copyright © 1963 by The American Society for Clinical Nutrition, Inc.

Enhancement of Calcium Absorption in Man by a Bile Acid Sequestrant

ANNE M. BRISCOE PH.D.1 and CHARLES RAGAN M.D.1

1 From the Departments of Medicine and Biochemistry, Columbia University, College of Physicians and Surgeons, and the First (Columbia University) Medical Division, Bellevue Hospital, New York, New York

Cholestyramine, a bile sequestering polymer, administered orally for short periods of time, altered the intestinal absorption of calcium, phosphorus, nitrogen and fat in human subjects maintained on constant diets in a metabolism ward.

In six of seven studies in three subjects, the apparent intestinal absorption of fat was decreased while that of phosphorus was increased in five. In all seven, the amount of calcium retained in the body increased during the period of cholestryamine administration despite an increased urinary output, because of greater decreases in fecal excretion. Over-all nitrogen retention was observed in six studies and phosphorus retention in five. The effect of the drug was reproducible at two different levels of calcium intake and two levels of physical activity.

The implications of these findings in the mechanism of calcium absorption from the intestine are discussed.






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