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American Journal of Clinical Nutrition, Vol 13, 312-317, Copyright © 1963 by The American Society for Clinical Nutrition, Inc.

Vitamin Unresponsiveness

Progression of Classic Signs of Neuropathy and Pellagra During Therapy

LESLIE ZIEVE M.D.1 and EARL HILL M.D.1

1 From the Department of Medicine, Laboratory for Cancer Research and Radioisotope Service, Minneapolis Veterans Hospital, University of Minnesota, Minneapolis, Minnesota

Cases are presented illustrating a state of unresponsiveness to thiamin and niacin. Manifestations of neuropathy and of pellagra appeared and progressed even though the patients were receiving adequate doses of thiamin and niacin. We suggest that this unresponsiveness may be related to a deficiency of cofactors necessary for the effective utilization of these vitamins by the tissues.




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