American Journal of Clinical Nutrition, Vol 16, 165-172, Copyright © 1965 by The American Society for Clinical Nutrition, Inc.

Changes in Plasma and Erythrocyte Lipids During Short-Term Administration of Intravenous Fat Emulsion and Its Subfractions

¹ From The Division of Nutrition, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, Ohio

Results are reported of a twelve day study of three groups of human subjects who were given a fat emulsion (group 1), a fat emulsion minus cottonseed oil (group 2) and a fat emulsion minus cottonseed oil and soya phosphatide (group 3). It is shown that the fat emulsion and the fat emulsion without the cottonseed oil causes a decrease in blood hematocrit. Although the whole emulsion causes a slight increase in plasma cholesterol, phospholipids and triglycerides, the fat emulsion without cottonseed oil causes increases in these components. The plasma diene (linoleic acid) doubles after administration of the fat emulsion, and there is a concomitant decrease in trienoic, tetraenoic, pentaenoic and hexaenoic fatty acids. A decrease shown primarily in the plasma tetraene occurs after administration of the emulsion without the cottonseed oil. Erythrocyte dienoic fatty acid increases 50 per cent after administration of both the fat emulsion and the fat emulsion without cottonseed oil, which suggests that the entire phospholipid moiety is incorporated into red blood cells. None of these changes are observed after infusion of the pluronic-glucose emulsion.