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American Journal of Clinical Nutrition, Vol 16, 75-79, Copyright © 1965 by The American Society for Clinical Nutrition, Inc.

Acute Studies with Single Infusions of Fat Emulsions in Dogs

A. RICHARD VELA PH.D.1, ROY R. MARRERO M.S.1, and ISIDORE COHN JR. M.D.1

1 From the Department of Surgery, Louisiana State University School of Medicine, New Orleans, Louisiana

The effects of a single infusion of various fat emulsions on the arterial blood pressure and on lymph flow, bile flow, pancreatic juice and gastric secretions were studied in normal dogs.

The SR-151 emulsion had the least effect on the arterial blood pressure. Most other emulsions had a delayed hypotensive effect, usually 30 to 60 minutes after the infusion. The pronounced fall in blood pressure noted during the infusion of some of the emulsions was associated with a marked increase in lymph flow.

None of the emulsions had an effect on bile flow or on pancreatic or gastric secretions. The presence of fat in the thoracic duct lymph, bile and pancreatic juice was visually negligible.

Acute animal testing may be an effective method for detecting acute toxicity of the various emulsions and for screening of emulsions prior to long-term administration.






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Copyright © 1965 by The American Society for Nutrition