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American Journal of Clinical Nutrition, Vol 16, 80-87, Copyright © 1965 by The American Society for Clinical Nutrition, Inc.

Long-Term Intravenous Administration of Fat Emulsions in Dogs and Single Infusions in Man

A. RICHARD VELA PH.D.1, QUENTIN L. HARTWIG PH.D.1, MOHAMMAD ATIK M.D.1, ROY R. MARRERO M.S.1, and ISIDORE COHN JR. M.D.1

1 From the Department of Surgery, Louisiana State University School of Medicine, New Orleans, Louisiana

The effects of the chronic administration of several intravenous fat emulsions to normal dogs have been studied. The emulsions were administered in larger amounts than is generally recommended for man in order to study any latent toxicity and thus test the safety of the emulsions.

Some major effects noted following multiple infusions of fat include lethargy, anorexia, weight loss, vomiting, lipemia, anemia and leukocytosis. The incidence and severity of these effects varied with the emulsions.

An experimental SR emulsion was given to clinical patients, but discontinued after ill effects were noted.

The new SR-151 emulsion was found to be the best tolerated emulsion in dogs. The side effects encountered with this emulsion were minimal even after multiple infusions of 8 gm. fat per kg. per day.






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Copyright © 1965 by The American Society for Nutrition