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American Journal of Clinical Nutrition, Vol 16, 252-255, Copyright © 1965 by The American Society for Clinical Nutrition, Inc.

Cholesterol Metabolism

IV. Studies of Intestinal Hydrolysis of Cholesterol Acetate

DANIEL K. BLOOMFIELD M.D.1

1 From the Department of Medicine, Western Reserve University School of Medicine, Cleveland, Ohio

Intestinal hydrolysis of cholesterol acetate in rats was studied by analysis of free and total sterol content in the feces. Hydrolysis increased as the concentrations of cholesterol acetate in the diet increased, but the efficiency of hydrolysis in terms of completeness diminished. When the concentration of cholesterol acetate in the diet was constant, hydrolysis increased as dietary fat increased. Finally, the paradoxical absorption of cholesterol 4-C14 indicates that if cholesterol ester is absorbed intact, the locus differs from that of free cholesterol absorption.






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Copyright © 1965 by The American Society for Nutrition