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American Journal of Clinical Nutrition, Vol 17, 57-63, Copyright © 1965 by The American Society for Clinical Nutrition, Inc.

Zinc Metabolism and Chronic Alcoholism

JAMES F. SULLIVAN M.D., F.A.C.P.1 and HAL G. LANKFORD PH.D.1

1 From the Departments of Medicine and Pathology of The Creighton University School of Medicine

Previous studies have shown that patients with Laennec's cirrhosis have low serum and hepatic zinc levels, but excrete excessive amounts of zinc in the urine. The urinary excretion of zinc in noncirrhotic alcoholic subjects was studied. In forty-two of 124 chronic alcoholic subjects the excretion of zinc in the urine was found to be abnormally high. Age, duration of alcoholism, blood level of alcohol and rate of alcohol metabolism could not be correlated with the abnormality in zinc excretion. The abnormal zincuria was transient, disappearing within two weeks in 80 per cent of of those studied. Abnormal zinc excretion was present in each of the seven patients diagnosed as having delerium tremens. The occurrence of this abnormality of zinc excretion in chronic alcoholic subjects and in those with postalcohohic cirrhosis is of uncertain significance. The possibility that zinc deficiency may occur in these conditions seems likely.




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