AJCN Tufts Nutrition Symposium, Boston Sept 24-26
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow An erratum has been published
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MCLAREN, D. S.
Right arrow Articles by AJANS, Z. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MCLAREN, D. S.
Right arrow Articles by AJANS, Z. A.
Agricola
Right arrow Articles by MCLAREN, D. S.
Right arrow Articles by AJANS, Z. A.

American Journal of Clinical Nutrition, Vol 17, 131-138, Copyright © 1965 by The American Society for Clinical Nutrition, Inc.

Biochemical and Hematologic Changes in the Vitamin A-Deficient Rat

D. S. MCLAREN M.D., PH.D., D.T.M.& H.1, MARIE TCHALIAN B.SC.1, and Z. A. AJANS M.D.1

1 From the Institute of Nutrition Sciences, Columbia University, New York, New York, and the Nutrition Research Laboratory, American University of Beirut, Beirut, Lebanon

In an initial experiment it was shown that in severely vitamin A-deficient rats (experimental group) there is a significant rise in hemoglobin and hematocrit, total plasma protein, beta globulin, gamma globulin and vitamin E levels.

Further evidence is provided for the direct relationship between growth rate and vitamin A requirements.

In a second experiment the hemoconcentration phenomenon and increases in plasma proteins occurred in the early stage of vitamin A deficiency and the values returned to normal eleven days after treatment with the vitamin.

The close correlation between hematocrit and body weight in both control and experimental groups, before and after treatment, and the rapidity with which these changes occur, strongly suggest that vitamin A deficiency causes hemoconcentration through retardation of growth and not through its action on hemopoietic tissues.




This article has been cited by other articles:


Home page
 BloodHome page
S. Ghatpande, A. Ghatpande, J. Sher, M. H. Zile, and T. Evans
Retinoid signaling regulates primitive (yolk sac) hematopoiesis
Blood, April 1, 2002; 99(7): 2379 - 2386.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1965 by The American Society for Nutrition