American Journal of Clinical Nutrition, Vol 18, 100-104, Copyright © 1966 by The American Society for Clinical Nutrition, Inc.

Influence of Variable Quantities of Methionine on Nitrogen Retention of Adult Human Subjects

¹ From Purdue University Agricultural Experiment Station and School of Home Economics, Department of Foods and Nutrition, Purdue University, Lafayette, Indiana

Nitrogen retention in six men was measured when the following diets were fed: a basal diet containing 200 gm. of white wheat flour and a small quantity of lysine which furnished 320 mg. of methionine and 770 mg. of cystine; experimental diets containing 320, 470, 620 and 920 mg. of methionine together with 770 mg. of cystine; and a control diet supplying 1.5 times the reported minimal requirements of all essential amino acids. The methionine equivalents of the experimental diets were 1,270, 1,420, 1,570 and 1,870 mg. Nitrogen balances resulting from the different treatments did not differ significantly from each other but certain trends were observed. The smallest quantity of methionine was inadequate for two men, and the two largest amounts induced a more uniform response than did the others. A wide zone of tolerance for methionine was observed under these experimental conditions.

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