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American Journal of Clinical Nutrition, Vol 19, 10-16, Copyright © 1966 by The American Society for Clinical Nutrition, Inc.

Assay of the Autohumoral Antibody that Neutralizes the Vitamin B12 Combining Site of Intrinsic Factor in Serum from Patients with Pernicious Anemia

H. J. HANSEN PH.D.1, O. N. MILLER PH.D.1, and C. H. TAN M.D.1

1 From the Department of Biochemical Research, Touro Research Institute and the Departments of Biochemistry and Medicine, Tulane University School of Medicine, New Orleans, Louisiana

A simple rapid method is described to assay the antibody (combining site antibody—CSAB) in serum from patients with pernicious anemia which neutralizes the vitamin B12 combining site of human intrinsic factor. Of the serums obtained from patients in whom pernicious anemia was diagnosed previously, 50 per cent were found to contain the antibody. Thirteen of fourteen patients in whom pernicious anemia was not diagnosed previously were found to have the antibody in their serums, whereas patients with macrocytic anemia due to dietary folic acid deficiency, gastrectomy, malabsorption and Dilantin toxicity did not have the antibody.




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D. W. Sonneborn and H. J. Hansen
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Copyright © 1966 by The American Society for Nutrition