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American Journal of Clinical Nutrition, Vol 19, 237-246, Copyright © 1966 by The American Society for Clinical Nutrition, Inc.

Folate Synthesis by Intestinal Bacteria

FREDERICK A. KLIPSTEIN M.D.1 and I. MICHAEL SAMLOFF M.D.1

1 From the Department of Medicine, Columbia University College of Physicians and Surgeons, the Francis Delafield Hospital, New York, New York, and the Hôpital Albert Schweitzer, Deschapelles, Haiti

Growth of coliform organisms or enterococci was obtained from jejunal aspirates taken from twenty-one of twenty-three Haitian subjects who had either tropical sprue, protein malnutrition, or were asymptomatic. These bacteria were shown to be capable of synthesizing monoglutamate forms of folate as well as 5-methyltetrahydrofolic acid or pteroyltriglutamate, or both. In addition, the finding that folate concentrations of the supernatant were higher after growth in a source of conjugated folate than following growth in crystalline folic acid suggests that folate deconjugase was elaborated during growth of these bacteria.

Although the role of folate synthesized by intestinal bacteria in the nutrition of the host remains to be established, these observations may represent a partial explanation for the low incidence of folate deficiency that has been observed in patients with malabsorption in Haiti.




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T. H. Kim, J. Yang, P. B. Darling, and D. L. O'Connor
A Large Pool of Available Folate Exists in the Large Intestine of Human Infants and Piglets
J. Nutr., June 1, 2004; 134(6): 1389 - 1394.
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