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American Journal of Clinical Nutrition, Vol 20, 1-4, Copyright © 1967 by The American Society for Clinical Nutrition, Inc.

The Folate Binding in Milk

JACOBO GHITIS M.D.1 and CRISTINA LORA M.T.1

1 From the Department of Medicine, Universidad del Valle Medical School, Cali, Colombia, South America

The free-folic acid activity of milk appears to be bound to a protein. The binding seems to be highly specific, as it is not broken by autoclaving. Synthetic PGA, but not 4-amino-10-methyl PGA, is able to bind to milk. This binding seems to be semispecific only, the bond being broken by autoclaving.

Two types of vitamin B12 binding also appear to be present in milk. Autoclaved milk may be deprived completely of its free folic acid activity but only partially of its vitamin B12 activity through adsorption with activated charcoal.




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Copyright © 1967 by The American Society for Nutrition