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American Journal of Clinical Nutrition, Vol 20, 250-252, Copyright © 1967 by The American Society for Clinical Nutrition, Inc.

Metabolism of l-Ascorbic-4-3H Acid in Man

BERT M. TOLBERT 1, AGNES W. CHEN 1, ELLEN M. BELL 1, and EUGENE M. BAKER 1

1 From Department of Chemistry, University of Colorado, Boulder, and U.S. Army Medical Research and Nutrition Laboratory, Denver, Colorado

The kinetic and metabolic fate of ascorbic-4-3H acid has been studied in a human subject. The radioactive label does not enter the body water pool, but instead is excreted as organic-bound tritium. The excretion products were found to be ascorbic acid and its immediate oxidation products, and unknown organic compound(s). Kinetic analysis of the data shows half times of 2 days and 46 days for turnover of the labeled ascorbic acid and the unknown compound, respectively. These results, combined with previous ascorbate-I-14C studies, indicate that the unknown metabolite(s) are probably derivative(s) of l-threose or l-threonic acid.




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 International Journal of ToxicologyHome page
Final Report of the Safety Assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as Used in Cosmetics
International Journal of Toxicology, March 1, 2005; 24(2_suppl): 51 - 111.
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Copyright © 1967 by The American Society for Nutrition