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American Journal of Clinical Nutrition, Vol 20, 297-304, Copyright © 1967 by The American Society for Clinical Nutrition, Inc.

Vitamin A Therapy in Children with Kwashiorkor

SHEILA M. PEREIRA M.B.B.S., M.R.C.P.E.1, ALMAS BEGUM M.S.C.1, THILAKAVATHY ISAAC M.SC.1, and MARY E. DUMM PH.D.1

1 From the Department of Nutrition Research of The Christian Medical College and Hospital, Vellore, South India

Oral and intramuscular administration of oily and water-miscible preparations of vitamin A was tried in children with kwashiorkor and in normal controls.

Intramuscular injections of vitamin A in oil did not raise serum levels in all children with protein-calorie malnutrition.

Vitamin A in oil orally administered was poorly absorbed in children with kwashiorkor during their first few days in the hospital.

Water-miscible vitamin A by oral or intramuscular routes elevated serum levels rapidly in patients and controls. Absorption of oral water-miscible A was erratic.

Based on these results a single intramuscular injection of 100,000 IU of water-miscible palmitate is recommended for the initial treatment of children with kwashiorkor and severe vitamin A deficiency.






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Copyright © 1967 by The American Society for Nutrition