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American Journal of Clinical Nutrition, Vol 20, 443-445, Copyright © 1967 by The American Society for Clinical Nutrition, Inc.

Failure of Long-Term Oral Vitamin B12 Therapy to Replenish Body B12 Stores

EUGENE A. BRODY M.D.1

1 From the Department of Hematology, The Mount Sinai Hospital, New York City

A patient with pernicious anemia in relapse was treated with orally administered vitamin B12, 50 µg t.i.d. for 10 years, Clinical, hematological, and neurological remission was maintained during this period, but serum vitamin B12 levels never rose above low normal values. A section of normal liver removed at surgery after the 10-year period had a low B12 concentration.

This suggests that oral treatment of pernicious anemia in these doses is sufficient to correct the clinical and hematological abnormalities but is not sufficient to increase the body stores of vitamin B12 to normal in 10 years.






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Copyright © 1967 by The American Society for Nutrition