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American Journal of Clinical Nutrition, Vol 20, 702-707, Copyright © 1967 by The American Society for Clinical Nutrition, Inc.

Vitamin B6 Content of Human Arterial and Venous Tissue

T. KHEIM M.D.1 and J. E. KIRK M.D., PH.D.2

1 Research Instructor, Division of Gerontology, Washington University School of Medicine, St. Louis, Missouri
2 Director of Research, Division of Gerontology, Washington University School of Medicine, St. Louis, Missouri

Quantitative determinations were made of the vitamin B6 content in intima-media layers of various types of human vascular tissue. The assays were made microbiologically on acid tissue hydrolyzates with the use of Neurospora sitophila 229 (ATCC 9276), a microorganism which responds equally to pyridoxal, pyridoxamine, and pyridoxine. When expressed as pyridoxine, an average vitamin B6 concentration of 0.311 µg/g of fresh tissue was found in normal aortic specimens. Higher contents were displayed by pulmonary artery, coronary artery, and vena cava samples. Moderately lower levels were recorded for lipid-arteriosclerotic than for normal vascular tissue; this difference was more pronounced in male than in female subjects. No significant correlation was found between assayed pyridoxine concentrations and arterial transaminase activities.






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Copyright © 1967 by The American Society for Nutrition