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American Journal of Clinical Nutrition, Vol 21, 51-56, Copyright © 1968 by The American Society for Clinical Nutrition, Inc.
1 From the Departments of Medicine and Biochemistry, University of Arkansas School of Medicine, Little Rock, Arkansas
Vitamin E-deficient monkeys develop anemia due to ineffective erythropoiesis. The anemia can be effectively treated with vitamin E but not with other well-known hematopoietic substances. However, treatment with a coenzyme Q that is native to the monkey (coenzyme Q10) causes reticulocytosis, and treatment with hexahydrocoenzyme Q4 induces a complete remission of the anemia. In related experiments, we found evidence that vitamin E and coenzyme Q can act together to improve the stability of cellular membranes, and we suggest that this interaction may explain the response of vitamin E-deficient animals to coenzyme Q therapy.
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