AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by NITZAN, M.
Right arrow Articles by LARON, Z.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by NITZAN, M.
Right arrow Articles by LARON, Z.
Agricola
Right arrow Articles by NITZAN, M.
Right arrow Articles by LARON, Z.

American Journal of Clinical Nutrition, Vol 21, 1268-1273, Copyright © 1968 by The American Society for Clinical Nutrition, Inc.

Metabolic Substrates and Hormones During Starvation Ketosis in Children

MENACHEM NITZAN M.D.1, AVIVA KOWADLO-SILBERGELD B.SC.1, MICHAEL DORON 1, and ZVI LARON M.D.1

1 From the Department of Pediatrics, Pediatric Metabolic and Endocrine Service, and Rogoff-Wellcome Trust Medical Research Institute, Beilinson Medical Center, Petah Tikva, and Tel Aviv University Medical School, Israel

A study has been undertaken to obtain some insight into the metabolic events occurring during the development of nondiabetic ketosis in children.

Blood sugar and plasma FFA, glycerol, insulin, GH, and 11-OHCS concentrations were assessed in 12 children admitted to the hospital with ketosis associated with persistent vomiting and markedly restricted food intake. Similar determinations were performed a few days later, following the disappearance of the ketosis. Thus, each ketotic child served as his own control when he was in the recovery phase.

An adjustment to a new fuel mixture, which contained an increased proportion of FFA and glycerol, took place during the ketotic period. At the same time, blood sugar remained within the normal range. No demonstrable elevation of plasma GH was found in the ketotic state. This fact casts some doubt on any possible effect of GH on the disposition of metabolic fuels during this type of nondiabetic ketosis in children. However, the relative decrease in insulin and the increase in 11-OHCS observed during the ketotic stage suggest that these hormones may play a role in the regulation of energy metabolism during fasting.




This article has been cited by other articles:


Home page
 PediatricsHome page
A. Kelly, R. Tang, S. Becker, and C. A. Stanley
Poor Specificity of Low Growth Hormone and Cortisol Levels During Fasting Hypoglycemia for the Diagnoses of Growth Hormone Deficiency and Adrenal Insufficiency
Pediatrics, September 1, 2008; 122(3): e522 - e528.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1968 by The American Society for Nutrition