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American Journal of Clinical Nutrition, Vol 21, 1314-1320, Copyright © 1968 by The American Society for Clinical Nutrition, Inc.
1 Departments of Medicine and Child Health, University of Cape Town
Fasting plasma free tryptophan concentrations were significantly reduced in a small sample of untreated pellagrins. In pellagrous children, tryptophan was no lower than in kwashiorkor. But the branched-chain amino acids and tyrosine, though moderately reduced, were higher than in kwashiorkor. In the adult pellagrins, only plasma tryptophan was low. The branched-chain amino acids and tyrosine were normal.
Plasma tryptophan may prove to be a convenient biochemical test to confirm the diagnosis of pellagra on a blood sample.
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