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American Journal of Clinical Nutrition, Vol 21, 1314-1320, Copyright © 1968 by The American Society for Clinical Nutrition, Inc.

Plasma Tryptophan and Other Amino Acids in Pellagra

A. S. TRUSWELL M.D., M.R.C.P.1, J. D. L. HANSEN M.D., F.R.C.P., D.C.H.1, and PATRICIA WANNENBURG 1

1 Departments of Medicine and Child Health, University of Cape Town

Fasting plasma free tryptophan concentrations were significantly reduced in a small sample of untreated pellagrins. In pellagrous children, tryptophan was no lower than in kwashiorkor. But the branched-chain amino acids and tyrosine, though moderately reduced, were higher than in kwashiorkor. In the adult pellagrins, only plasma tryptophan was low. The branched-chain amino acids and tyrosine were normal.

Plasma tryptophan may prove to be a convenient biochemical test to confirm the diagnosis of pellagra on a blood sample.







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