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American Journal of Clinical Nutrition, Vol 21, 1438-1444, Copyright © 1968 by The American Society for Clinical Nutrition, Inc.

Hormonal Profile and Forearm Metabolism in Human Obesity

DAVID RABINOWITZ M.D.1

1 From the Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland

Subjects with simple obesity display hyperinsulinism and blunted HGH responsiveness. Examination of forearm metabolism obese subjects reveals a hormonal pattern compatible with basal hyperinsulinism. Furthermore, there is peripheral resistance to all the actions of insulin that we have examined. Important questions remain regarding the etiology of the insulin resistance associated with, and quantitative fatty acid utilization in, obesity.






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Copyright © 1968 by The American Society for Nutrition