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American Journal of Clinical Nutrition, Vol 21, 473-481, Copyright © 1968 by The American Society for Clinical Nutrition, Inc.

Absorption Tests with Natural Folate Material in Controls and in Gastrectomized Patients

T. MARKKANEN M.D.1

1 From the Department of Medicine and the Department of Medical Microbiology of the University of Turku, Finland

Folic acid absorption tests wete performed on 100 test subjects, using ground calf liver as substrate. The dose was 1.0 g/kg of body weight. The FA content of the liver was 8.4 µg/g. Forty-two of the 100 subjects were controls, and 58 had been gastrectomized. On a part of the material (23 controls and 26 gastrectomized patients) the FA absorption test was performed without preceding FA saturation. For the others (19 controls and 32 gastrectomized) the test was performed after saturation. The SeFA level was followed for 6 hr.

The meal produced a definite rise in time SeFA level of all the control subjects; the peak was usually reached in 1-2 hr. The SeFA curves for about one-third of the non-saturated gastrectomized patients and for about one-tenth of the saturated gastrectomized patients were flat.

The conclusion reached was that the FA deficiency of the gastrectomized patients was in most cases attributable to factors (e.g., Suboptimal intake) other than reduced absorption. Absorption may be reduced in about one-tenth of the gastrectomized patients.

Liver tissue proved to be a suitable material for FA absorption tests. Small quantities of liver tissue (under 1.0 g/kg) are sufficient to raise the SeFA level. The liver tissue material probably retains its FA activity best when stored in the form of freeze-dried powder.




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Copyright © 1968 by The American Society for Nutrition