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American Journal of Clinical Nutrition, Vol 21, 482-487, Copyright © 1968 by The American Society for Clinical Nutrition, Inc.

Studies on Growth Hormone Secretion in Protein-Calorie Malnutrition

B. L. PIMSTONE M.D., M.R.C.P.1, G. BARBEZAT M.D.1, J. D. L. HANSEN M.D., M.R.C.P., D.C.H.1, and P. MURRAY B.SC. (HONS.)1

1 From the Departments of Medicine and Child Health, University of Cape Town, and the Red Cross War Memorial Children's Hospital, Cape, South Africa

Human growth hormone levels are raised in nutritional marasmus, as has been found in kwashiorkor. In the individual untreated case the degree of elevation appears to correlate with the severity of the protein depletion as measured by a low plasma albumin concentration. The high HGH values in kwashiorkor are not affected by increasing the calorie intake and fall only when protein is added to the diet.

These results suggest that chronic protein deprivation acts as a stimulus to growth hormone secretion.






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