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American Journal of Clinical Nutrition, Vol 21, 736-738, Copyright © 1968 by The American Society for Clinical Nutrition, Inc.

Conversion of Glucuronolactone into Ascorbic Acid in Man

N. CHANDRASEKHARA 1, M. V. L. RAO 1, and M. SRINIVASAN 1

1 From the Discipline of Biochemistry, Central Food Technological Research Institute, Mysore, India

Contrary to the reports of Baker and associates (3, 7), neither oral ingestion nor intravenous administration of d-glucuronolactone caused any large increases in the plasma level or urinary excretion of ascorbic acid in six human volunteers. Even after raising the plasma levels of ascorbic acid by ingesting the vitamin over a period, these subjects did not register any better response when the lactone was given. Further, ingestion of the lactone itself for a period of 6 days failed to raise the plasma levels of ascorbic acid.






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Copyright © 1968 by The American Society for Nutrition