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American Journal of Clinical Nutrition, Vol 21, 820-826, Copyright © 1968 by The American Society for Clinical Nutrition, Inc.

Experimental Protein-Calorie Malnutrition

R. E. KIRSCH M.B., CH.B.1, J. F. BROCK D.M., F.R.C.P.2, and S. J. SAUNDERS M.D., M.R.C.P., F.C.P.(S.A.)3

1 Research Bursar, Clinical Nutrition Unit, Department of Medicine, University of Cape Town, Cape Town, South Africa
2 Professor and Head of Department of Medicine, University of Cape Town and Chief Physician, Groote Schuur Hospital and Associated Teaching Hospitals, Cape Town
3 Senior Lecturer and Senior Physician, Department of Medicine, University of Cape Town and Groote Schuur Hospital

Rats fed a diet containing 5% mixed protein developed clinical, biochemical, and histological disorders similar to those seen in children suffering from kwashiorkor. Growth was markedly decreased, edema occurred in most animals, and they developed significant hypoalbuminemia, a plasma amino acid profile similar to that seen in kwashiorkor, and histological evidence of periportal fatty infiltration in the liver.






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