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American Journal of Clinical Nutrition, Vol 21, 892-897, Copyright © 1968 by The American Society for Clinical Nutrition, Inc.

Uric Acid Production of Men Fed Graded Amounts of Egg Protein and Yeast Nucleic Acid

CAROL I. WASLIEN 1, DORIS HOWES CALLOWAY 1, and SHELDON MARGEN 1

1 From the Department of Nutritional Sciences, University of California, Berkeley, California 94720

Healthy male subjects were fed purine-free basal diets containing 0-75 g of protein and, at the highest protein level, 0-8 g of added yeast ribonucleic acid in order to differentiate effects of these dietary components on plasma and urinary uric acid production. Urinary uric acid levels were significantly higher and plasma levels lower with 75 g of protein than with a protein-free diet. When nucleic acid was fed, plasma and urinary uric acid increased linearly in four of five subjects. Predictive equations were derived describing this response to dietary nucleic acid.




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