American Journal of Clinical Nutrition, Vol 21, 904-910, Copyright © 1968 by The American Society for Clinical Nutrition, Inc.

Interactions of Obesity, and Glucose and Insulin Levels in Hypertriglyceridemia

¹ From the Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio

Twenty subjects representing a wide range of average plasma triglyceridle levels were studied. They were given a 3-hr oral glucose tolerance test during which glucose and immunoreactive insulin levels were measured at hourly intervals. Average triglyceride levels were found to be significantly correlated with several measures of obesity, and with the levels of glucose and insulin observed during the glucose tolerance test. Multivariate analysis revealed that triglyceride levels were correlated positively with glucose levels, independent of their correlations with the other variables. Relative body weight and the insulin response to oral glucose were highly interrelated and acted together as another factor which was significantly correlated with plasma triglyceride levels. The present data and those of others are consistent with the concept that fasting triglyceride levels in hypertriglyceridemic patients may be determined by the blood levels of insulin and glucose, and that insulin levels are highly dependent upon the degree of obesity present.

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