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American Journal of Clinical Nutrition, Vol 22, 1420-1422, Copyright © 1969 by The American Society for Clinical Nutrition, Inc.

Triiodothyronine and Mercurial Diuretics

Effects on Excretion of a Water Load and on Plasma Free Fatty Acids in Obese Patients

GEORGE A. BRAY M.D.1, JOSEPH A. GLENNON M.D.1, BERNARD RÜEDI M.D.1, PHILIP CHEIFETZ M.D.1, and CARL E. CASSIDY M.D.1

1 From the New England Medical Center Hospitals and the Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts

Sixteen obese patients were hospitalized on the Clinical Study Unit of the New England Medical Center Hospitals and fed a 1,320-kcal diet for 24 days. The excretion of a water load and the rise in plasma free fatty acids were measured before, and at the end of, treatment. Six patients were treated with small daily doses of triiodothyronine and two injections of a mercurial diuretic. Four others received only the diuretic and six only the diet. At the end of treatment, the patients who had received triiodothyronine showed a smaller rise in plasma free fatty acids following injection of epinephrine and excreted a smaller amount of water after a water load.






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Copyright © 1969 by The American Society for Nutrition