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American Journal of Clinical Nutrition, Vol 22, 1426-1428, Copyright © 1969 by The American Society for Clinical Nutrition, Inc.

Suppression of Uric Acid Formation from Dietary Nucleic Acid with Allopurinol

JEAN BOWERING M.N.S.1, SHELDON MARGEN M.D.1, DORIS HOWES CALLOWAY PH.D.1, and APRIL RHYNE B.S.1

1 From the Department of Nutritional Sciences, University of California, Berkeley, California 94720

In a controlled human metabolic study, addition of 8 g/day of yeast RNA to a low protein, purine-free formula diet produced elevated serum and urinary uric acid levels that could be reduced by allopurinol, an inhibitor of uric acid formation. Administration of 100 mg/day of allopurinol also led to a rise in urinary hypoxanthine + xanthine, which was less than the fall in urinary uric acid. Since total oxypurine excretion was reduced, it appears that allopurinol effectively suppresses both endogenous purine synthesis and synthesis of uric acid from exogenous purines.






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Copyright © 1969 by The American Society for Nutrition