AJCN Tufts Nutrition Symposium, Boston Sept 24-26
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American Journal of Clinical Nutrition, Vol 22, 1469-1475, Copyright © 1969 by The American Society for Clinical Nutrition, Inc.

Vitamin Distribution in Red Blood Cells, Plasma, and Other Body Fluids

HERMAN BAKER 1, OSCAR FRANK 1, ALLAN D. THOMSON 1, and SUSAN FEINGOLD 1

1 From the Division of Hepatic Metabolism and Nutrition, Department of Medicine, New Jersey College of Medicine and Dentistry, and East Orange Veterans Administration Hospital, East Orange, New Jersey

The distribution of vitamins in red blood cells and plasma was determined in seven healthy volunteers. On a volume basis red blood cells were richer than plasma in riboflavin, nicotinate, pantothenate, thiamine, and reduced folates; vitamins A, E, and oxidized pteroylmonoglutamates were undetectable in red blood cells. Vitamins A and E, biotin, B6, B12, and oxidized pteroyltriglutamates together with N5-methyltetrahydrofolate (N5-methyl-THF) were mainly concentrated in plasma as compared with red blood cells; ascorbate was almost equally distributed between red blood cells and plasma. An intravenous multivitamin loading dose produced a large increase of biotin, pantothenate, B6, thiamine, and oxidized pteroyltriglutamates plus N5-methyl-THF in the red blood cell; increases in red blood cell nicotinate, riboflavin, and B12 were minimal. No increase in red blood cell ascorbate, vitamins A and E, and oxidized and reduced pteroylmonoglutamates occured despite their immersion in the vitamin-loaded plasma. Red blood cells seem poorly permeable to these vitamins and such levels are, therefore, not a dependable index of vitamin status at the the blood is drawn. Presumably, most B vitamins and vitamin A quickly concentrate in tissues and other fluids other than the plasma or red blood cells. Folates were the exception; like vitamin E they remained mostly in the plasma.

Urinary recovery of intravenous multivitamins varied from undetectable amounts (vitamins A, E, and oxidized pteroyltriglutamates) to 100% (biotin). Only 1.2% of hydroxocobalamin as compared to 19% of cyanocobalamin was recovered in urine indicating a greater body retention of hydroxocobalamin.






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Copyright © 1969 by The American Society for Nutrition