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American Journal of Clinical Nutrition, Vol 22, 1559-1562, Copyright © 1969 by The American Society for Clinical Nutrition, Inc.

Plasma Amino Acid Concentration and the Regulation of Albumin Synthesis

R. E. KIRSCH M.D.1, S. J. SAUNDERS M.D., M.R.C.P., F.C.P.1, L. FRITH B.SC.1, S. WICHT B.SC.1, L. KELMAN M.B., CH.B.1, and J. F. BROCK D.M., F.R.C.P.1

1 From the Liver Research Group and Clinical Nutrition Unit, Department of Medicine, University of Cape Town, Cape Town, South Africa

Amino acid concentration as a factor regulating albumin synthesis in protein-depletion states was tested by perfusing livers with blood from malnourished animals in which the concentration of branched-chain amino acids was reduced. These livers synthesized significantly less albumin than did livers perfused with normal blood. Addition of branched-chain amino acids to the perfusate restored the albumin synthesis rate to normal.




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