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American Journal of Clinical Nutrition, Vol 22, 1563-1567, Copyright © 1969 by The American Society for Clinical Nutrition, Inc.

Tryptophan Intake, Spacing of Meals, and Diurnal Fluctuations of Plasma Tryptophan in Men

VERNON R. YOUNG 1, MOHAMMED A. HUSSEIN 1, EDWINA MURRAY 1, and NEVIN S. SCRIMSHAW 1

1 From the Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

The influence of adequate and low tryptophan intakes and the spacing of meals on the concentration of tryptophan in blood plasma of normal adult men was examined. For both levels of dietary tryptophan, when four meals were given daily, at 8:00 AM, 12:00 noon, 4:00 PM, and 9:00 PM, the plasma tryptophan level rose between 1:00 AM and 8:00 AM and decreased between 8:00 AM and 12:00 noon. Plasma tryptophan concentration did not increase in the early morning hours when six meals were offered at 4-hr intervals throughout the day.




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