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American Journal of Clinical Nutrition, Vol 22, 311-314, Copyright © 1969 by The American Society for Clinical Nutrition, Inc.

Insulin and Intestinal Sugar Absorption

DAVID FROMM M.D.1

1 Research Fellow in Surgery, Harvard Medical School and Beth Israel Hospital, 330 Brookline Avenue, Boston, Massachusetts 02215

1) Insulin has been shown to increase glucose absorption from isolated rat small intestine in vivo; this effect was proportional to the dose of insulin. An effect of insulin has not been demonstrated with intubation-perfusion studies in man. Fundamental differences in methodology, however, prevent a direct comparison of these conflicting results.

2) Insulin has been shown to increase sugar transport in vitro across small intestine from normal animals.

3) There is no convincing evidence that the enhanced sugar absorption in vivo and in vitro of diabetes mellitus is altered by insulin.

4) The physiological significance of the enhancement of intestinal sugar absorption by insulin in normal animals is not clear.






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Copyright © 1969 by The American Society for Nutrition