AJCN Tufts Nutrition Symposium, Boston Sept 24-26
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American Journal of Clinical Nutrition, Vol 22, 318-326, Copyright © 1969 by The American Society for Clinical Nutrition, Inc.

Existence and Characteristics of Na+-Dependent Active Transport of Ascorbic Acid in Guinea Pig

NANCY R. STEVENSON M.S.1 and MIRIAM K. BRUSH PH.D.2

1 Predoctoral Fellow of the National Institutes of Health
2 Asso-ciate Professor, Department of Home Economics and Adjunct Associate Professor, Department of Nutrition, Davison Hall, Douglass College, New Brimnswick, New jersey 08903

In contrast to the rat and hamster, the guinea pig has an active transport mechanism for the intestinal absorption of ascorbic acid, involving ascorbic acid as the mobile form of the vitamin. This active transport has all of the accepted properties of a gradient-coupled, Na+-dependent transport system, similar to, but distinct from, that for sugars. It is concluded to be a species-specific transport mechanism related to a species-specific nutrient requirement.




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