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American Journal of Clinical Nutrition, Vol 22, 871-877, Copyright © 1969 by The American Society for Clinical Nutrition, Inc.

Intestinal Uptake of Valine in Calorie and Protein Deprivation

MANFRED STEINER M.D., PH.D.1, GROVER C. M. FARRISH M.D.1, and SEYMOUR J. GRAY M.D., PH.D.1

1 From the Massachusetts Institute of Technology, Department of Nutrition and Food Science, Cambridge, Massachusetts

Time uptake of l-valine by intestinal mucosa obtained by peroral biopsies of the midjejunum was studied in six obese subjects before and after a period of complete starvation. The tissue accumulation of amino acid showed the characteristics of a saturable process. After a 2-week period of starvation, accompanied by an average weight loss of 9.5 kg, there was a marked, statistically significant reduction in amino acid uptake at all the concentrations of l-valine tested. After starvation, valine uptake fell into the range of normal-weight controls. The effect of protein deprivation on amino acid uptake was investigated in three normal-weight adults. No consistent difference between uptakes before and after protein restriction was found. Total water space, extracellular water, and nitrogen content of intestinal mucosa were unaffected by total starvation or protein restriction.






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Copyright © 1969 by The American Society for Nutrition