AJCN 19th International Congress of Nutrition
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American Journal of Clinical Nutrition, Vol 22, 1139-1141, Copyright © 1969 by The American Society for Clinical Nutrition, Inc.

Blood Keto Acids in Malnutrition

G. A. O. ALLEYNE M.D., M.R.C.P.1 and G. H. SCULLARD B.SC.1

1 From the Medical Research Council, Tropical Metabolism Research Unit, University of the West Indies, Mona, Kingston 7, Jamaica, West Indies

Blood pyruvate and agr-ketoglutarate were measured in seven children while they were suffering from protein-calorie malnutrition and again after complete recovery. There was no change in pyruvate or agr-ketoglutarate with clinical recovery. The data are interpreted to mean that there is no metabolic block in the oxidation of pyruvate via the Krebs cycle. Also, normal levels of agr-ketoglutarate might indicate that there was no severe derangement of hepatic excretory function in the children studied.






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