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American Journal of Clinical Nutrition, Vol 23, 114-118, Copyright © 1970 by The American Society for Clinical Nutrition, Inc.

Effect of a Single Massive Dose of Vitamin A on Serum and Liver Levels of the Vitamin

S. G. SRIKANTIA M.B., B.S., D.SC.1 and VINODINI REDDY M.D., D.C.H.1

1 From the Nutrition Research Laboratories, Indian Council of Medical Research, Tarnaka, Hyderabad-7, India

Studies were carried out to determine the effects of administering a large single dose of oil-soluble and water-miscible preparations of vitamin A by different routes on serum vitamin A levels in children as well as the hepatic storage in animals. The results showed that the maximal hepatic storage was achieved by the oral administration of an oil-soluble preparation although the highest serum levels were obtained with parenteral administration of water-miscible preparations.

It was observed that the administration of 300,000 IU of an oil-soluble preparation of Vitamin A given as a single dose to undernourished children was able to sustain levels of serum vitamin A in the normal range for as long a period as 6 months.






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Copyright © 1970 by The American Society for Nutrition