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American Journal of Clinical Nutrition, Vol 23, 119-122, Copyright © 1970 by The American Society for Clinical Nutrition, Inc.

Field Prophylactic Trial with a Single Annual Oral Massive Dose of Vitamin A

M. C. SWAMINATHAN M.B., B.S., M.P.H.1, T. P. SUSHEELA M.B., B.S.1, and B. V. S. THIMMAYAMMA M.A.1

1 From the Nutrition Research Laboratories, Indian Council of Medical Research, Tarnaka, Hyderabad-7, India

With the objective of preventing vitamin A deficiency, about 2,000 preschool children were administered an annual, massive, single dose of 300,000 IU of vitamin A. The results of the follow-up study over a period of 2 years indicate a considerable reduction in the prevalence of signs of vitamin A deficiency. In order to attain better prophylaxis it is suggested that the frequency of administration of the massive dose be increased to once every 6 months instead of once every year.




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