AJCN 19th International Congress of Nutrition
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American Journal of Clinical Nutrition, Vol 23, 371-376, Copyright © 1970 by The American Society for Clinical Nutrition, Inc.

Studies of Bladder Stone Disease in Thailand

XI. Effect of 4-Hydroxy-l-Proline and Orthophosphate Supplementations on Crystalluria

SAKORN DHANAMITTA M.D.1, AREE VALYASEVI M.D.1, and ROBERT VAN REEN PH.D.1

1 From Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand and the Naval Medical Research Institute, Bethesda, Maryland

Fifteen male infants living in a hyperendemic area of bladder stone disease (Ubol villages), whose ages ranged from 6 to 12 months, were given oral supplementations of 4-hydroxy-l-proline and orthophosphate. It was found that oxalate crystalluria was markedly increased and clumping of crystals occurred after oral hydroxy-l-proline supplementation. The orthophosphate supplements reduced crystalluria and clumping. The possible role of hydroxyproline in bladder stone formation is discussed.






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Copyright © 1970 by The American Society for Nutrition