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American Journal of Clinical Nutrition, Vol 23, 379-381, Copyright © 1970 by The American Society for Clinical Nutrition, Inc.

Importance of Urine Volume in Assessment of Thiamin Deficiency

W. G. DEWHURST M.B., M.R.C.P., D.P.M.1 and H. G. MORGAN M.B., M.R.C.P., D.P.M.1

1 Senior Lecturer, Institute of psychiatry, de Crespingney Park, London S.E.5. England

The urinary output of thiamin after an intramuscular load is shown to be a linear function of the rate of urine flow in the 4 hr after injection. The regression equation is Ycirc = 0.1462 + 1.404 X where X is the 4-hr urine volume in liters and Ycirc is the predicted thiamin output as log percentage dose. The regression coefficient is highly significant (P < 0.001). The relevance of this finding to the diagnosis of thiamin deficiency and the possible occurrence with other metabolites are discussed.






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