AJCN Tufts Nutrition Symposium, Boston Sept 24-26
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American Journal of Clinical Nutrition, Vol 23, 645-651, Copyright © 1970 by The American Society for Clinical Nutrition, Inc.

Metabolic Effects of Nonabsorbable Antibacterial Agents

WILLIAM W. FALOON M.D.1

1 From the Department of Medicine, Highland Hospital, and the University of Rochester School of Medicine and Dentistry, Rochester, New York 14620

Although they are effective agents for the treatment of hepatic coma when given orally, the poorly absorbed wide-spectrum antibacterial drugs such as neomycin have significant metabolic effects. These are chiefly related to the production of a reversible malabsorption syndrome that appears to be due to a combination of bile-salt binding and mucosal injury. Relatively few of these intestinal changes are related to the antibacterial properties of neomycin. Understanding the possible hazards (and benefits) induced by this and similar poorly absorbed compounds may lead to their improved use in a variety of clinical problems as well as in hepatic coma.






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Copyright © 1970 by The American Society for Nutrition